How obesity causes inflammation.

08:31 am Friday 18 October 2019

The link between obesity and inflammation and why it is important to know.

We all know that high calorie intake results in weight gain. What is not commonly talked about or known is that excess calorie intake results in inflammation. This inflammation can be seen in multiple organs including body fat, liver, skeletal muscle, pancreas and central nervous system. In the state of obesity fat cells increase in both number and size.

During the process of weight gain fat cells both increase in number and become larger in size. Subsequently the blood supply to these cells is compromised resulting in reduced oxygen delivery and partial cell death. This process results in infiltration of macrophages, a type of immune cell, into the body fat. The increase in the number of both fat cells and these immune cells results in excess release of proteins that promote inflammation (pro-inflammatory) in the body. These inflammatory proteins have a negative effect on liver, fat cells and pancreas resulting in increased fasting blood sugar and insulin level. We now better understand the association between obesity and the type of proteins that fight inflammation (anti-inflammatory), and how the amount of these proteins is reduced when one has obesity.

This collective increase of the inflammatory proteins and decrease in anti-inflammatory proteins in obesity contributes to sustained inflammation resulting in development of cardiometabolic conditions such as atherosclerosis, metabolic syndrome, insulin resistance and type 2 diabetes mellitus. It can also contribute to non-cardiometabolic conditions such as psoriasis, depression, cancer, and renal disease.

At Metta Weight Management (NJ Weight Loss Clinic), we work with our patients to treat their obesity and underlying medical conditions caused by excess weight gain. We understand the link between obesity and inflammation and how diet plays a significant role in reducing inflammation. We partner with our patients to prescribe a meal plan that best matches their lifestyle and medical profile.